Issue 56, 2015
From the journal:

RSC Advances

A Pd(ii)-catalyzed C–H activation approach to densely functionalized N-heteroaromatics related to neocryptolepine and their evaluation as potential inducers of apoptosis†

Rajnikanth Sunke,a   Vimal Kumar,a   Mohd Ashraf Ashfaq,a   Swapna Yellanki,ab   Raghavender Medisetti,ab   Pushkar Kulkarni,ab   E. V. Venkat Shivaji Ramarao,a   Nasreen Z. Ehteshamc  and  Manojit Pal*a  

* Corresponding authors

a Dr. Reddy's Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad 500 046, India
E-mail: manojitpal@rediffmail.com
Tel: +91 40 6657 1500

b Zephase Therapeutics (an incubated company at the DRILS), University of Hyderabad Campus, Gachibowli, Hyderabad 500 046, India

c National Institute of Pathology, Safdarjang Hospital Campus, New Delhi-110029, India

Abstract

11-Carboxymethyl substituted 6H-indolo[2,3-b]quinolines, which are potential inducers of apoptosis, were obtained by one-pot Pd(II)-catalyzed intramolecular oxidative C3–H alkenylation of the indole ring of (E)-alkyl-3-(2-(1H-indol-2-ylamino)phenyl)acrylate derivatives followed by desulfonylation.

Graphical abstract: A Pd(ii)-catalyzed C–H activation approach to densely functionalized N-heteroaromatics related to neocryptolepine and their evaluation as potential inducers of apoptosis

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Article information

DOI
https://doi.org/10.1039/C5RA06764B
Article type
Communication
Submitted
15 Apr 2015
Accepted
01 May 2015
First published
04 May 2015

RSC Adv., 2015,5, 44722-44727

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A Pd(II)-catalyzed C–H activation approach to densely functionalized N-heteroaromatics related to neocryptolepine and their evaluation as potential inducers of apoptosis

R. Sunke, V. Kumar, M. A. Ashfaq, S. Yellanki, R. Medisetti, P. Kulkarni, E. V. V. Shivaji Ramarao, N. Z. Ehtesham and M. Pal, RSC Adv., 2015, 5, 44722 DOI: 10.1039/C5RA06764B

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