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Issue 63, 2015
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Pyridoxal-thiosemicarbazide: its anion sensing ability and application in living cells imaging

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Abstract

A new anion selective chemosensor L was derived through a direct condensation reaction between pyridoxal and thiosemicarbazide. Sensor L showed selective recognition and sensing ability towards F and AcO anions through a naked-eye detectable color change from colorless to light yellow, appearance of a new charge transfer absorption band at 404 nm and significant “turn-on” fluorescence at 506 nm. The detection limit of L as a fluorescent ‘turn-on’ sensor for the analysis of F and AcO was estimated to be 0.10 μM. The anion sensing mechanisms of L was supported by 1H NMR and DFT results. Finally, the cytotoxicity effect of L and its ability to image intracellular F ions in the living HeLa cells was investigated.

Graphical abstract: Pyridoxal-thiosemicarbazide: its anion sensing ability and application in living cells imaging

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Publication details

The article was received on 22 Mar 2015, accepted on 03 Jun 2015 and first published on 03 Jun 2015


Article type: Paper
DOI: 10.1039/C5RA05059F
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Citation: RSC Adv., 2015,5, 50741-50746

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    Pyridoxal-thiosemicarbazide: its anion sensing ability and application in living cells imaging

    D. Sharma, A. Moirangthem, R. Kumar, S. K. Ashok Kumar, A. Kuwar, J. F. Callan, A. Basu and S. K. Sahoo, RSC Adv., 2015, 5, 50741
    DOI: 10.1039/C5RA05059F

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