Jump to main content
Jump to site search

Issue 52, 2015
Previous Article Next Article

Fabrication of acrylic acid grafted guar gum-multiwalled carbon nanotube hydrophobic membranes for transdermal drug delivery

Author affiliations

Abstract

Environmentally stable acrylic acid (AA) grafted guar gum (GG)-carboxy functionalized multiwalled carbon nanotube (f-MWCNT) in situ composite membranes for the sustained release of a hydrophobic drug, namely, diclofenac sodium, have been developed and characterized. Absolute matrix–filler interaction, particularly up to 1 wt% f-MWCNT concentration, instigated finer dispersion of the filler and subsequent increase in the water resistance and drug retention properties of the composites compared to the 2 and 3 wt% levels. The latter showed non-uniform filler networking and eventually resulted in poor water resistance and drug retention behaviors. The slowest drug release was achieved at the 1 wt% f-MWCNT level and fastest was observed at 3 wt% (21.5% vs. 48.5%). The releases followed a non-Fickian mechanism with the greater influence of viscoelastic relaxation at 0.5 and 1 wt% compositions compared to 2 and 3 wt% compositions, respectively.

Graphical abstract: Fabrication of acrylic acid grafted guar gum-multiwalled carbon nanotube hydrophobic membranes for transdermal drug delivery

Back to tab navigation

Article information


Submitted
03 Mar 2015
Accepted
23 Apr 2015
First published
08 May 2015

RSC Adv., 2015,5, 41736-41744
Article type
Paper

Fabrication of acrylic acid grafted guar gum-multiwalled carbon nanotube hydrophobic membranes for transdermal drug delivery

A. Giri, T. Bhunia, L. Goswami, A. B. Panda and A. Bandyopadhyay, RSC Adv., 2015, 5, 41736
DOI: 10.1039/C5RA03782D

Social activity

Search articles by author

Spotlight

Advertisements