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Issue 34, 2015
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Cytotoxic saponin poliusaposide from Teucrium polium

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Abstract

Three saponin glycosides have been isolated and characterized from Teucrium polium L. (Lamiaceae). The compounds were isolated from a MeOH aerial plant extract. The structures were elucidated based on spectroscopic methods including UV, IR, 1D and 2D NMR, and HRESIMS data analyses. The identified compounds were evaluated for anticancer effects against 60 human tumor cell lines (NCI). The triterpene glycoside, poliusaposide C completely inhibited the growth of a breast and colon cancer cell line and partially inhibited the growth of a colon, renal and melanoma cell line. Structure–anticancer activity relationships are discussed.

Graphical abstract: Cytotoxic saponin poliusaposide from Teucrium polium

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Supplementary files

Article information


Submitted
11 Feb 2015
Accepted
11 Mar 2015
First published
17 Mar 2015

RSC Adv., 2015,5, 27126-27133
Article type
Paper
Author version available

Cytotoxic saponin poliusaposide from Teucrium polium

W. A. Elmasri, M. F. Hegazy, Y. Mechref and P. W. Paré, RSC Adv., 2015, 5, 27126
DOI: 10.1039/C5RA02713F

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