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Issue 28, 2015
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Ultrasound assisted multicomponent reactions: a green method for the synthesis of highly functionalized selenopyridines using reusable polyethylene glycol as reaction medium

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Abstract

A simple and benign one-pot protocol for the synthesis of 2-amino selenopyridine derivatives 4 has been developed using ultrasound assisted multicomponent reactions of aldehydes, malononitrile and benzeneselenol in polyethylene glycol (PEG-400). Under similar reaction conditions, sterically hindered o,o′-disubstituted aromatic aldehydes provide the corresponding functionalized seleno dihydropyridines 5. In this process in total four new bonds (two C–C, one C–N and one C–Se) forms in one pot.

Graphical abstract: Ultrasound assisted multicomponent reactions: a green method for the synthesis of highly functionalized selenopyridines using reusable polyethylene glycol as reaction medium

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Publication details

The article was received on 07 Feb 2015, accepted on 19 Feb 2015 and first published on 19 Feb 2015


Article type: Communication
DOI: 10.1039/C5RA02403J
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RSC Adv., 2015,5, 22168-22172

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    Ultrasound assisted multicomponent reactions: a green method for the synthesis of highly functionalized selenopyridines using reusable polyethylene glycol as reaction medium

    Md. N. Khan, S. Karamthulla, L. H. Choudhury and Md. S. Haque Faizi, RSC Adv., 2015, 5, 22168
    DOI: 10.1039/C5RA02403J

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