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Issue 29, 2015
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Regioselective copper-catalyzed thiolation of imidazo[1,2-a]pyridines: an efficient C–H functionalization strategy for C–S bond formation

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Abstract

A highly regioselective C–H/S–H cross-coupling of imidazo[1,2-a]pyridines with thiols has been developed using molecular oxygen to form the C-3 sulfenated products in the presence of a copper catalyst. It represents a simple process for the formation of C–S bonds to prepare thioether-decorated imidazo[1,2-a]pyridines. The reaction proceeds smoothly with a broad range of substrates to give imidazo[1,2-a]pyridines in good yields.

Graphical abstract: Regioselective copper-catalyzed thiolation of imidazo[1,2-a]pyridines: an efficient C–H functionalization strategy for C–S bond formation

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Publication details

The article was received on 23 Jan 2015, accepted on 20 Feb 2015 and first published on 20 Feb 2015


Article type: Communication
DOI: 10.1039/C5RA01342A
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RSC Adv., 2015,5, 22356-22360

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    Regioselective copper-catalyzed thiolation of imidazo[1,2-a]pyridines: an efficient C–H functionalization strategy for C–S bond formation

    H. Cao, L. Chen, J. Liu, H. Cai, H. Deng, G. Chen, C. Yan and Y. Chen, RSC Adv., 2015, 5, 22356
    DOI: 10.1039/C5RA01342A

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