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Issue 42, 2015
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Targeted imaging of brain gliomas using multifunctional Fe3O4/MnO nanoparticles

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Abstract

Integrating T1- and T2-components of magnetic resonance (MR) imaging into a single particle has been demonstrated to be effective for improving the diagnostic accuracy. However, a T1T2 dual modal MR contrast agent with glioma targeting ability remains unexplored. In this study, we prepared gourd-shaped Fe3O4/MnO hybrid NPs with a size of 25 nm through a thermal decomposition method. The water dispersibility was then obtained via a ligand exchange process with carboxylic acid-terminated silane. The sequential conjugation of chlorotoxin (CTX) and Cy5.5 on the carboxyl groups of attached silane endowed Fe3O4/MnO hybrid NPs with near-infrared fluorescence and glioma-targeting characteristics. The in vitro studies confirmed the targeting ability of Fe3O4/MnO–Cy5.5–CTX NPs toward C6 glioma cells. The in vivo T1T2 dual modal MR imaging of glioma-bearing brain verified that the CTX conjugation led to a better contrast enhancement of the tumour tissue from the normal tissue both in T1 and T2 imaging, comparing to unconjugated NPs, which could enable more accurate diagnosis of gliomas.

Graphical abstract: Targeted imaging of brain gliomas using multifunctional Fe3O4/MnO nanoparticles

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Supplementary files

Article information


Submitted
19 Jan 2015
Accepted
30 Mar 2015
First published
30 Mar 2015

RSC Adv., 2015,5, 33639-33645
Article type
Paper

Targeted imaging of brain gliomas using multifunctional Fe3O4/MnO nanoparticles

S. Li, C. Shao, W. Gu, R. Wang, J. Zhang, J. Lai, H. Li and L. Ye, RSC Adv., 2015, 5, 33639
DOI: 10.1039/C5RA01069A

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