Palladium-catalyzed oxygenation of C(sp2)–H and C(sp3)–H bonds under the assistance of oxalyl amide

Abstract

A practical palladium-catalyzed γ-oxygenation of C(sp²)–H and C(sp³)–H bonds under the assistance of oxalyl amide with PhI(OAc)₂ as oxidant was developed. Selective alkoxylation or acetoxylation of oxalyl amide protected benzyl amine was achieved in high yield. The oxalyl amide protected α-substituted propylamines could be transformed into acetoxylated products in good to excellent yields.