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Issue 27, 2015
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Molecular insight and resolution for tumors harboring the H-ras(G12V) mutation

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Abstract

A study about the physiological regulators of oncogenic growth has recently been published in the literature. When the H-ras gene mutates, the mutant H-ras(G12V) protein causes uncontrolled cell growth. We tried to observe whether there is any difference between the wild type and mutant H-ras protein in terms of the molecular character and structural variation in silico. Our hypothesis is that the H-ras(G12V) protein, accompanied by an altered structure, might be responsible for excess signal transduction and even tumor formation. In this study, we wanted to find a potent compound that could bind to the H-ras(G12V) protein and interfere with the phosphorylation of the substrate protein. By using homology modeling, structure-based docking, candidate screening, and molecular dynamics (MD) simulations, we demonstrated that the structural and molecular character of the H-ras and H-ras(G12V) proteins were different. Abrine could bind to H-ras(G12V) and might interfere with the phosphorylation process. These results provided novel insight for the management of tumors or cancers, which harbor the H-ras(G12V) mutation.

Graphical abstract: Molecular insight and resolution for tumors harboring the H-ras(G12V) mutation

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Publication details

The article was received on 28 Dec 2014, accepted on 05 Feb 2015 and first published on 05 Feb 2015


Article type: Paper
DOI: 10.1039/C4RA16763E
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Citation: RSC Adv., 2015,5, 20623-20633

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    Molecular insight and resolution for tumors harboring the H-ras(G12V) mutation

    H. Tang and Y. Chen, RSC Adv., 2015, 5, 20623
    DOI: 10.1039/C4RA16763E

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