Issue 4, 2015

Silver(i) ions modulate the stability of DNA duplexes containing cytosine, methylcytosine and hydroxymethylcytosine at different salt concentrations

Abstract

Silver(I) ions can stabilize cytosine–cytosine, cytosine (C)–methylcytosine (5mC) and cytosine–hydroxymethylcytosine (5hmC) mismatched-base pairs. While cytosine modifications regulate DNA stability to regulate cellular functions, silver ions can modulate the stability of C–C, C–5mC and C–5hmC containing DNA duplexes in a salt concentration dependent manner.

Graphical abstract: Silver(i) ions modulate the stability of DNA duplexes containing cytosine, methylcytosine and hydroxymethylcytosine at different salt concentrations

Supplementary files

Article information

Article type
Communication
Submitted
13 Nov 2014
Accepted
04 Dec 2014
First published
04 Dec 2014

RSC Adv., 2015,5, 2655-2658

Silver(I) ions modulate the stability of DNA duplexes containing cytosine, methylcytosine and hydroxymethylcytosine at different salt concentrations

Y. Wang, B. Ritzo and L. Gu, RSC Adv., 2015, 5, 2655 DOI: 10.1039/C4RA14490B

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