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Issue 6, 2015
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Self-assembly of a cholesteryl-modified nucleoside into tubular structures from giant unilamellar vesicles

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Abstract

We recently reported the formation of micro- and nanometer thick tubules in a binary system of cholesteryl-modified aminouridine and a phosphatidylcholine in aqueous solution upon cooling from 70 °C to room temperature (Pescador et al., Chem. Commun, 2010, 46, 5358). To better understand the first steps of the tubular self-assembly and the role of the phospholipid, we investigated now morphological changes of phosphatidylcholine giant unilamellar vesicles upon incorporation of the conjugate at room temperature. We observed formation of needle-like structures organized in rosettes or bundles within hours to days depending on the mole fraction of the conjugate and preparation technique. Transmission electron microscopy revealed that the needle-like structures were 100–200 nm thick tubules with the inner lumen diameters of 15–40 nm. The tube self-assembly occurred at room temperature, which is important for further development of biomedical applications.

Graphical abstract: Self-assembly of a cholesteryl-modified nucleoside into tubular structures from giant unilamellar vesicles

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Publication details

The article was received on 26 Sep 2014, accepted on 04 Dec 2014 and first published on 05 Dec 2014


Article type: Paper
DOI: 10.1039/C4RA11289J
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RSC Adv., 2015,5, 4502-4510
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    Self-assembly of a cholesteryl-modified nucleoside into tubular structures from giant unilamellar vesicles

    L. Losensky, S. Chiantia, G. Holland, M. Laue, A. Petran, J. Liebscher and A. Arbuzova, RSC Adv., 2015, 5, 4502
    DOI: 10.1039/C4RA11289J

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