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Issue 102, 2014
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Total synthesis of MECA-79

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Abstract

The MECA-79 antigen is a sulfated mucin type core-1 extended O-glycan which is a potential anti-inflammatory agent. Herein we report a total synthesis of MECA-79 via a convergent [2 + 2] glycosylation route. The synthesis relies on efficient transformation of D-glucosamine into the orthogonally protected Tn antigen derivative and its elaboration into the TF antigen en route to MECA-79.

Graphical abstract: Total synthesis of MECA-79

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Publication details

The article was received on 08 Sep 2014, accepted on 23 Oct 2014 and first published on 29 Oct 2014


Article type: Paper
DOI: 10.1039/C4RA12631A
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RSC Adv., 2014,4, 58573-58580

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    Total synthesis of MECA-79

    A. Behera, M. Emmadi and S. S. Kulkarni, RSC Adv., 2014, 4, 58573
    DOI: 10.1039/C4RA12631A

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