Issue 102, 2014

Total synthesis of MECA-79

Abstract

The MECA-79 antigen is a sulfated mucin type core-1 extended O-glycan which is a potential anti-inflammatory agent. Herein we report a total synthesis of MECA-79 via a convergent [2 + 2] glycosylation route. The synthesis relies on efficient transformation of D-glucosamine into the orthogonally protected Tn antigen derivative and its elaboration into the TF antigen en route to MECA-79.

Graphical abstract: Total synthesis of MECA-79

Supplementary files

Article information

Article type
Paper
Submitted
08 Sep 2014
Accepted
23 Oct 2014
First published
29 Oct 2014

RSC Adv., 2014,4, 58573-58580

Author version available

Total synthesis of MECA-79

A. Behera, M. Emmadi and S. S. Kulkarni, RSC Adv., 2014, 4, 58573 DOI: 10.1039/C4RA12631A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements