Issue 82, 2014

Chemodosimeter approach for nanomolar detection of Cu2+ ions and their bio-imaging in PC3 cell lines

Abstract

A new rhodamine–azaindole based receptor 4 has been synthesized which selectively senses Cu2+ ions via a fluorescence resonance energy transfer (FRET) process in acetonitrile while in mixed aqueous media it undergoes Cu2+ promoted hydrolysis among the various metal ions tested (Pb2+, Ba2+, Fe3+, Cd2+, Ag+, Zn2+, Hg2+, Cu2+, Ni2+, Co2+, Fe2+ and Mg2+). The time resolved fluorescence studies also support the Cu2+ promoted hydrolysis of receptor 4 in mixed aqueous media. The detection limit for Cu2+ ions has been found to be 20 nM. The potential biological application of probe 4 is evaluated for in vitro detection of copper ions in prostate cancer (PC3) cell lines.

Graphical abstract: Chemodosimeter approach for nanomolar detection of Cu2+ ions and their bio-imaging in PC3 cell lines

Supplementary files

Article information

Article type
Paper
Submitted
19 Aug 2014
Accepted
01 Sep 2014
First published
01 Sep 2014

RSC Adv., 2014,4, 43470-43476

Author version available

Chemodosimeter approach for nanomolar detection of Cu2+ ions and their bio-imaging in PC3 cell lines

S. I. Reja, V. Bhalla, S. Manchanda, G. Kaur and M. Kumar, RSC Adv., 2014, 4, 43470 DOI: 10.1039/C4RA08894H

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