Issue 84, 2014
From the journal:

RSC Advances

Facile preparation of 3,5-disubstituted-4-aminothiophene-2-carbaldehyde from a novel unexpected domino reaction of vinyl azides and 1,4-dithiane-2,5-diol†

Binhui Chen,a   Hangcheng Ni,a   Xiao Guo,a   Guolin Zhang*a  and  Yongping Yu*a  

* Corresponding authors

a Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Science, Zhejiang University, Hangzhou 310058, P. R. China
E-mail: guolinzhang@zju.edu.cn, yyu@zju.edu.cn
Tel: +86-571-8820-8450

Abstract

A simple and direct synthesis of 3,5-disubstituted-4-aminothiophene-2-carbaldehyde from vinyl azides and 1,4-dithiane-2,5-diol was developed. An attractive feature of this protocol is that the desired products are generated in a highly efficient and eco-friendly manner. A plausible mechanism has been proposed.

Graphical abstract: Facile preparation of 3,5-disubstituted-4-aminothiophene-2-carbaldehyde from a novel unexpected domino reaction of vinyl azides and 1,4-dithiane-2,5-diol

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Article information

DOI
https://doi.org/10.1039/C4RA08649J
Article type
Communication
Submitted
14 Aug 2014
Accepted
08 Sep 2014
First published
08 Sep 2014

RSC Adv., 2014,4, 44462-44465

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Facile preparation of 3,5-disubstituted-4-aminothiophene-2-carbaldehyde from a novel unexpected domino reaction of vinyl azides and 1,4-dithiane-2,5-diol

B. Chen, H. Ni, X. Guo, G. Zhang and Y. Yu, RSC Adv., 2014, 4, 44462 DOI: 10.1039/C4RA08649J

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