Synthesis of α, β and γ-carbolines via Pd-mediated Csp2-H/N–H activation†
Abstract
An efficient method for the synthesis of halo-carbolines has been developed via Pd-catalysed formation of C–N bonds through Csp2-H/N–H activation of 4-methyl-N-[2-(pyridine-3-yl)phenyl] benzenesulfonamide derivatives. Pd(OAc)2 in the presence of Cu(OAc)2 as oxidant afforded halo-carbolines in good to excellent yields with tolerance to a variety of substituents.