Issue 85, 2014

Design and fabrication of surface-enhanced Raman scattering substrate from DNA–gold nanoparticles assembly with 2–3 nm interparticle gap

Abstract

An ideal substrate for surface-enhanced Raman scattering (SERS) detection should induce a high signal enhancement and be easy to synthesize. Here, we showed that gold nanoparticles (Au NPs) were self-assembled onto DNA strands by electrostatic interactions and formed a well-defined DNA–Au hybrid structure with an interparticle gap of ca. 2–3 nm between two adjacent Au NPs, which could be used as active SERS substrates. Four different types of molecule, i.e. Rhodamine 6G, 4-aminothiophenol, pyridine and 2,4,6-trinitrotoluene, were studied on these substrates. All the detection limits for each analyte on the DNA–Au hybrid substrate were at least one order of magnitude higher than those on Au NPs alone without self-assembly on DNA. This phenomenon of assembly-induced signal enhancement has been experimentally and theoretically demonstrated in this study.

Graphical abstract: Design and fabrication of surface-enhanced Raman scattering substrate from DNA–gold nanoparticles assembly with 2–3 nm interparticle gap

Supplementary files

Article information

Article type
Paper
Submitted
17 Jul 2014
Accepted
01 Sep 2014
First published
02 Sep 2014

RSC Adv., 2014,4, 45207-45213

Author version available

Design and fabrication of surface-enhanced Raman scattering substrate from DNA–gold nanoparticles assembly with 2–3 nm interparticle gap

L. Zhang, H. Ma and L. Yang, RSC Adv., 2014, 4, 45207 DOI: 10.1039/C4RA06947A

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