Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 68, 2014
Previous Article Next Article

Synthesis of randomly aminated polyvinylpyrrolidone and its use in the preparation of hydrolyzable conjugates

Author affiliations

Abstract

In this work, a versatile synthetic route to functionalize vinylpyrrolidone (VP) with protected or unprotected aliphatic primary amine groups is described for the first time. Using these monomeric precursors polyvinylpyrrolidones (PVPs) with controlled load of side amine groups randomly distributed along the chains have been prepared. These functionalized VP and PVP systems are active molecules highly desirable for further couplings, i.e. they can easily afford the simple preparation of water soluble covalent side chain conjugates onto the PVP backbone. To show the potential of this functionalization, we have prepared functionalized polymers as a controlled release delivering vehicle, employing the bactericide and preservative 2-phenoxyethanol as a hydroxyl-containing model drug.

Graphical abstract: Synthesis of randomly aminated polyvinylpyrrolidone and its use in the preparation of hydrolyzable conjugates

Back to tab navigation

Supplementary files

Article information


Submitted
05 Jun 2014
Accepted
07 Aug 2014
First published
07 Aug 2014

RSC Adv., 2014,4, 35950-35958
Article type
Paper
Author version available

Synthesis of randomly aminated polyvinylpyrrolidone and its use in the preparation of hydrolyzable conjugates

A. D. Prado, R. Navarro, A. Gallardo, C. Elvira and H. Reinecke, RSC Adv., 2014, 4, 35950
DOI: 10.1039/C4RA05354K

Social activity

Search articles by author

Spotlight

Advertisements