Jump to main content
Jump to site search

Issue 68, 2014
Previous Article Next Article

Synthesis of randomly aminated polyvinylpyrrolidone and its use in the preparation of hydrolyzable conjugates

Author affiliations

Abstract

In this work, a versatile synthetic route to functionalize vinylpyrrolidone (VP) with protected or unprotected aliphatic primary amine groups is described for the first time. Using these monomeric precursors polyvinylpyrrolidones (PVPs) with controlled load of side amine groups randomly distributed along the chains have been prepared. These functionalized VP and PVP systems are active molecules highly desirable for further couplings, i.e. they can easily afford the simple preparation of water soluble covalent side chain conjugates onto the PVP backbone. To show the potential of this functionalization, we have prepared functionalized polymers as a controlled release delivering vehicle, employing the bactericide and preservative 2-phenoxyethanol as a hydroxyl-containing model drug.

Graphical abstract: Synthesis of randomly aminated polyvinylpyrrolidone and its use in the preparation of hydrolyzable conjugates

Back to tab navigation

Supplementary files

Publication details

The article was received on 05 Jun 2014, accepted on 07 Aug 2014 and first published on 07 Aug 2014


Article type: Paper
DOI: 10.1039/C4RA05354K
Author version
available:
Download author version (PDF)
Citation: RSC Adv., 2014,4, 35950-35958

  •   Request permissions

    Synthesis of randomly aminated polyvinylpyrrolidone and its use in the preparation of hydrolyzable conjugates

    A. D. Prado, R. Navarro, A. Gallardo, C. Elvira and H. Reinecke, RSC Adv., 2014, 4, 35950
    DOI: 10.1039/C4RA05354K

Search articles by author

Spotlight

Advertisements