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Issue 56, 2014
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Prussian blue nanoparticles for laser-induced photothermal therapy of tumors

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Abstract

We describe Prussian blue nanoparticles (PB NPs) for laser-induced photothermal therapy (PTT) of tumors. The PB NPs exhibit strong absorbance at near infrared (NIR) wavelengths, are stable, non-toxic, and have 20.5% photothermal conversion efficiencies. PTT with PB NPs in a mouse model of neuroblastoma resulted in marked tumor debulking, increased tumor-free days, and decreased tumor growth rates in tumor-bearing mice. These findings demonstrate the clinical potential of PB NPs for PTT of tumors.

Graphical abstract: Prussian blue nanoparticles for laser-induced photothermal therapy of tumors

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Supplementary files

Article information


Submitted
21 Apr 2014
Accepted
26 Jun 2014
First published
26 Jun 2014

RSC Adv., 2014,4, 29729-29734
Article type
Communication

Prussian blue nanoparticles for laser-induced photothermal therapy of tumors

H. A. Hoffman, L. Chakrabarti, M. F. Dumont, A. D. Sandler and R. Fernandes, RSC Adv., 2014, 4, 29729
DOI: 10.1039/C4RA05209A

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