Issue 43, 2014
From the journal:

RSC Advances

Solvent-free N-arylation of amines with arylboronic acids under ball milling conditions†

Xingyi Zhu,a   Qihong Zhanga  and  Weike Su*a  

* Corresponding authors

a Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, P.R. China
E-mail: pharmlab@zjut.edu.cn
Tel: +86 57188320899

Abstract

Solvent-free coupling reactions of arylboronic acids with various amines were presented under ball milling conditions, achieving the aromatic amine coupling products with yields ranging from moderate to good. This type of mechano-chemistry exhibited advantages of solvent-free property, high efficiency, simple work-up procedure and eco-friendliness.

Graphical abstract: Solvent-free N-arylation of amines with arylboronic acids under ball milling conditions

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Article information

DOI
https://doi.org/10.1039/C4RA02952F
Article type
Communication
Submitted
03 Apr 2014
Accepted
06 May 2014
First published
12 May 2014

RSC Adv., 2014,4, 22775-22778

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Solvent-free N-arylation of amines with arylboronic acids under ball milling conditions

X. Zhu, Q. Zhang and W. Su, RSC Adv., 2014, 4, 22775 DOI: 10.1039/C4RA02952F

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