Issue 38, 2014
From the journal:

RSC Advances

Phytic acid: a biogenic organocatalyst for one-pot Biginelli reactions to 3,4-dihydropyrimidin-2(1H)-ones/thiones†

Qiguo Zhang,a   Xin Wang,a   Zhenjiang Li,*a   Wenzhuo Wu,a   Jingjing Liu,a   Hao Wu,a   Saide Cuia  and  Kai Guo*a  

* Corresponding authors

a State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, China
E-mail: zjli@njtech.edu.cn, zjli.njtech@gmail.com, kaiguo@njtech.edu.cn
Fax: +86 25 5813 9935
Tel: +86 25 5813 9935

Abstract

The natural organocatalyst phytic acid catalyzed one-pot Biginelli reactions by coupling β-ketoesters, aldehydes, and (thio)ureas to afford 3,4-dihydropyrimidin-2(1H)-ones/thiones. This phytic acid catalysis featured good to excellent isolated yields, solvent-free conditions, a simple workup, environmental friendliness, and a short reaction time.

Graphical abstract: Phytic acid: a biogenic organocatalyst for one-pot Biginelli reactions to 3,4-dihydropyrimidin-2(1H)-ones/thiones

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Article information

DOI
https://doi.org/10.1039/C4RA02084G
Article type
Paper
Submitted
10 Mar 2014
Accepted
07 Apr 2014
First published
08 Apr 2014

RSC Adv., 2014,4, 19710-19715

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Phytic acid: a biogenic organocatalyst for one-pot Biginelli reactions to 3,4-dihydropyrimidin-2(1H)-ones/thiones

Q. Zhang, X. Wang, Z. Li, W. Wu, J. Liu, H. Wu, S. Cui and K. Guo, RSC Adv., 2014, 4, 19710 DOI: 10.1039/C4RA02084G

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