Local co-delivery and release of antimicrobial peptide and RGD using porous TiO2

Junjian Chen; Lin Wang; Lin Shi; Li Ren; Yingjun Wang

doi:10.1039/C4RA01983K

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Local co-delivery and release of antimicrobial peptide and RGD using porous TiO₂†

Junjian Chen,^abc Lin Wang,^abc Lin Shi,^abc Li Ren*^abc and Yingjun Wang*^abc

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* Corresponding authors

^a National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou 510006, China
E-mail: imwangyj@163.com, psliren@scut.edu.cn

^b School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China

^c Guangdong Province Key Laboratory of Biomedical Engineering, South China University of Technology, Guangzhou 510006, China

Abstract

We demonstrated for the first time the use of two kinds of porous TiO₂ films to co-deliver peptide HHC36 (KRWWKWWRR) and RGD. The film co-delivering these two peptides exhibited excellent antimicrobial activity against S. aureus and E. coli and low cytotoxicity to rat bone mesenchymal stem cells (rBMSCs).

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Article information

DOI: https://doi.org/10.1039/C4RA01983K
Article type: Communication
Submitted: 07 Mar 2014
Accepted: 23 May 2014
First published: 23 May 2014

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RSC Adv., 2014,4, 27630-27633

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Local co-delivery and release of antimicrobial peptide and RGD using porous TiO₂

J. Chen, L. Wang, L. Shi, L. Ren and Y. Wang, RSC Adv., 2014, 4, 27630 DOI: 10.1039/C4RA01983K

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