SCHEDULED MAINTENANCE
The current paper describes a new synthesis of heteroatom-substituted cyclooctynes. By using the Nicholas reaction we managed to design a concise synthesis that only uses three steps to build the eight-membered ring. It was also possible to functionalize said alkyne with a fluorophore.
T. Hagendorn and S. Bräse, RSC Adv., 2014, 4, 15493 DOI: 10.1039/C4RA01345J
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