Jump to main content
Jump to site search

Issue 33, 2014
Previous Article Next Article

Anti-HSV activity and mode of action study of α-pyrone carboxamides

Author affiliations

Abstract

The clinical management of herpes virus diseases is limited due to ineffective clearance of virus particles and frequent emergence of drug-resistant viruses, particularly in immunocompromised patients, pregnant women and neonates. In our continued quest for new antiviral leads, α-pyrone carboxamide propanol derivatives were synthesized and evaluated in HSV infected Vero cells. Compound 3d showed potent antiviral activity against HSV-IF (EC50 = 9.8 μg ml−1 and EC99 = 18.0 μg ml−1) and HSV-2G (EC50 = 12.4 μg ml−1 and EC99 = 24.0 μg ml−1) at 4–6 h post-infection. The mode of action studies demonstrated that 3d did not interfere in viral attachment or penetration, however, it reduced the expression of ICP4 and ICP27 (immediate-early gene products) as well as the HSV DNA polymerase.

Graphical abstract: Anti-HSV activity and mode of action study of α-pyrone carboxamides

Back to tab navigation

Supplementary files

Article information


Submitted
14 Feb 2014
Accepted
20 Feb 2014
First published
20 Feb 2014

RSC Adv., 2014,4, 17354-17363
Article type
Paper
Author version available

Anti-HSV activity and mode of action study of α-pyrone carboxamides

S. Karampuri, D. Ojha, P. Bag, H. Chakravarty, C. Bal, D. Chattopadhyay and A. Sharon, RSC Adv., 2014, 4, 17354
DOI: 10.1039/C4RA01303D

Social activity

Search articles by author

Spotlight

Advertisements