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Issue 24, 2014

Fabricating millimeter-scale polymeric structures for biomedical applications via a combination of UV-activated materials and daily-use tools

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Abstract

This paper describes an easy-to-handle approach to create three-dimensional millimeter-scale (or submillimeter-scale) polymeric structures on various substrates that have been used as molds in order to develop a polymeric-based manufacturing procedure for making in vitro diagnostic devices with mass production capacity and portability. These polymeric structures were made by using UV-activated materials, adhesive tapes as the mask, and a UV-LED flashlight as the portable light source. This straightforward approach can be easily performed and has great potential for use in resource-limited settings. The ability to conduct three common metabolic assays – for glucose, total cholesterol, and nitrite ions in this study – in both a buffer system and human serum (analytical validation, US FDA regulations) with clinically relevant sensitivity has been demonstrated using these polymeric-based in vitro diagnostic devices. This study, we believe, would provide for a wide range of potential applications such as the development of in vitro diagnostic devices, and a large-scale, low-cost, and easy-to-handle fabrication procedure for either developing regions or resource-limited settings, and, ultimately, for the development of “zero-cost” diagnostic devices for global public health.

Graphical abstract: Fabricating millimeter-scale polymeric structures for biomedical applications via a combination of UV-activated materials and daily-use tools

Supplementary files

Article information


Submitted
22 Jan 2014
Accepted
20 Feb 2014
First published
20 Feb 2014

RSC Adv., 2014,4, 12538-12544
Article type
Paper
Author version available

Fabricating millimeter-scale polymeric structures for biomedical applications via a combination of UV-activated materials and daily-use tools

C. Yang, C. Kuan, J. A. Yeh and C. Cheng, RSC Adv., 2014, 4, 12538 DOI: 10.1039/C4RA00631C

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