Issue 51, 2014
From the journal:

RSC Advances

Microwave irradiated synthesis of 2-bromo(chloro)indoles via intramolecular cyclization of 2-(gem-dibromo(chloro)vinyl)anilines in the presence of TBAF under metal-free conditions†

Min Wang,a   Pinhua Li,ab   Wei Chena  and  Lei Wang*ac  

* Corresponding authors

a Department of Chemistry, Huaibei Normal University, Huaibei, Anhui, P.R. China
E-mail: leiwang@chnu.edu.cn
Fax: +86 561-309-0518
Tel: +86 561-380-2069

b Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, P.R. China

c State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, P.R. China

Abstract

2-Bromo(chloro)indoles were readily and efficiently prepared through TBAF-promoted intramolecular cyclization of 2-(gem-dibromo(chloro)vinyl)anilines in excellent yields under metal-free and microwave irradiation conditions.

Graphical abstract: Microwave irradiated synthesis of 2-bromo(chloro)indoles via intramolecular cyclization of 2-(gem-dibromo(chloro)vinyl)anilines in the presence of TBAF under metal-free conditions

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Article information

DOI
https://doi.org/10.1039/C4RA00603H
Article type
Communication
Submitted
21 Jan 2014
Accepted
28 May 2014
First published
04 Jun 2014

RSC Adv., 2014,4, 26918-26923

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Microwave irradiated synthesis of 2-bromo(chloro)indoles via intramolecular cyclization of 2-(gem-dibromo(chloro)vinyl)anilines in the presence of TBAF under metal-free conditions

M. Wang, P. Li, W. Chen and L. Wang, RSC Adv., 2014, 4, 26918 DOI: 10.1039/C4RA00603H

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