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Issue 33, 2014
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Common precursor strategy for the synthesis of bestatin, amprenavir intermediate and syn-4-hydroxy-5-phenyl-γ-lactam

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Abstract

A common precursor strategy for the synthesis of bestatin hydrochloride, an anticancer agent, 1,3-diaminoalcohol, an amprenavir intermediate, and a syn-4-hydroxy-5-phenyl-γ-lactam intermediate of various bioactive molecules using an α,β-unsaturated ester as a common precursor is described. The protocol offers mild reaction conditions, good yields and excellent stereoselectivity.

Graphical abstract: Common precursor strategy for the synthesis of bestatin, amprenavir intermediate and syn-4-hydroxy-5-phenyl-γ-lactam

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Publication details

The article was received on 09 Jan 2014, accepted on 31 Mar 2014 and first published on 09 Apr 2014


Article type: Communication
DOI: 10.1039/C4RA00205A
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RSC Adv., 2014,4, 17206-17209

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    Common precursor strategy for the synthesis of bestatin, amprenavir intermediate and syn-4-hydroxy-5-phenyl-γ-lactam

    B. Kumar, M. A. Aga, A. Rouf, B. A. Shah and S. C. Taneja, RSC Adv., 2014, 4, 17206
    DOI: 10.1039/C4RA00205A

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