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Issue 28, 2014
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Synthesis of amidoalkyl chromen-2-ones by one pot three component reaction under solvent free conditions

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Abstract

A mild and efficient method for the functionalization of chromen-2-ones with amidoalkyl derivatives have been developed starting from 4-trifluoromethyl substituted chromen-2-ones, aromatic aldehydes and acetamide promoted by stannous chloride dihydrate in a one pot three component reaction under solvent free condition. Simple reaction conditions, high yields and environmentally benign procedure are the advantage of this protocol.

Graphical abstract: Synthesis of amidoalkyl chromen-2-ones by one pot three component reaction under solvent free conditions

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Article information


Submitted
08 Jan 2014
Accepted
11 Mar 2014
First published
12 Mar 2014

RSC Adv., 2014,4, 14501-14506
Article type
Paper

Synthesis of amidoalkyl chromen-2-ones by one pot three component reaction under solvent free conditions

N. R. Emmadi, K. Atmakur, M. Chennapuram and J. B. Nanubolu, RSC Adv., 2014, 4, 14501
DOI: 10.1039/C4RA00166D

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