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Issue 30, 2014
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Photoswitchable upconversion nanophosphors for small animal imaging in vivo

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Abstract

Photoswitchable upconversion luminescence nanoprobes (ps-UCNPs) are capable of adjusting the luminescent emission of upconversion nanocrystals and producing photoswitchable imaging by photochromism of molecular switch diarylethenes (DTEs). Here we present a rational, and simple strategy for constructing reversible ps-UCNPs based on NaYF4:Yb,Er,Tm nanocrystals and DTEs trapped in one nanosystem using BSA-graft-dextran copolymer as a shell to form a nanocapsule. In this nanosystem ps-UCNPs exhibited effective photochromic behavior and photoswitchable upconversion luminescence (UCL) which was controlled by alternating UV/visible light. Importantly, the ps-UCNPs showed low cytotoxicity and may be used as a photoswitchable UCL nanoprobe for in vitro and in vivo bioimaging. This is the first photoswitchable probe for mouse-level bioimaging in vivo. Our design strategy provides a versatile process for constructing a special photo-modulated probe in bioimaging.

Graphical abstract: Photoswitchable upconversion nanophosphors for small animal imaging in vivo

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Supplementary files

Article information


Submitted
11 Dec 2013
Accepted
17 Mar 2014
First published
18 Mar 2014

RSC Adv., 2014,4, 15613-15619
Article type
Paper

Photoswitchable upconversion nanophosphors for small animal imaging in vivo

T. Yang, Q. Liu, J. Li, S. Pu, P. Yang and F. Li, RSC Adv., 2014, 4, 15613
DOI: 10.1039/C3RA47529H

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