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Issue 13, 2014
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Zinc iodide: a mild and efficient catalyst for one-pot synthesis of aminoindolizines via sequential A3 coupling/cycloisomerization

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Abstract

ZnI2 was found to be an efficient catalyst for the synthesis of indolizine derivatives by a three-component coupling of pyridine-2-carboxaldehyde/quinoline-2-carboxaldehyde, secondary amines, and terminal alkynes in high yields. This protocol is compatible with a wide range of substrates and is expected to find broad applications due to its operational simplicity, shorter reaction time and low cost. A preliminary photophysical study showed that synthesized morpholinopyrrolo[1,2-a]quinolines represent a new class of fluorophore with high quantum yield.

Graphical abstract: Zinc iodide: a mild and efficient catalyst for one-pot synthesis of aminoindolizines via sequential A3 coupling/cycloisomerization

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Supplementary files

Article information


Submitted
08 Nov 2013
Accepted
23 Dec 2013
First published
24 Dec 2013

RSC Adv., 2014,4, 6672-6676
Article type
Communication

Zinc iodide: a mild and efficient catalyst for one-pot synthesis of aminoindolizines via sequential A3 coupling/cycloisomerization

S. Mishra, A. K. Bagdi, M. Ghosh, S. Sinha and A. Hajra, RSC Adv., 2014, 4, 6672
DOI: 10.1039/C3RA46513F

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