Issue 21, 2014

Folate and biotin based bifunctional quantum dots as fluorescent cell labels

Abstract

Although nanoprobes functionalized with one type of affinity molecule are commonly used as bioimaging probes, biolabeling studies of nanoprobes functionalized with more than one type of affinity molecule remains an unexplored area of research. Here we show that the labeling specificity of a nanoprobe can be enhanced if they are functionalized with more than one type of affinity molecule. We have synthesized functional quantum dots (QDs) of 20–30 nm hydrodynamic diameter having both folate and biotin on their surface. This dual functional nanoprobe has an enhanced labeling specificity to cancer cells/tissue as compared to folate or biotin based monofunctional QDs.

Graphical abstract: Folate and biotin based bifunctional quantum dots as fluorescent cell labels

Supplementary files

Article information

Article type
Paper
Submitted
24 Oct 2013
Accepted
19 Dec 2013
First published
20 Dec 2013

RSC Adv., 2014,4, 10434-10438

Folate and biotin based bifunctional quantum dots as fluorescent cell labels

A. Chakraborty, A. R. Maity and N. R. Jana, RSC Adv., 2014, 4, 10434 DOI: 10.1039/C3RA46085A

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