Issue 5, 2014
From the journal:

RSC Advances

Quantum dot based DNA nanosensors for amplification-free detection of human topoisomerase I†

Morten Leth Jepsen,a   Alessio Ottaviani,abc   Birgitta R. Knudsenab  and  Yi-Ping Ho*a  

* Corresponding authors

a Interdisciplinary Nanoscience Center (iNANO), Aarhus University, The iNANO House, Gustav Wieds Vej 14, DK-8000 Aarhus C, Denmark
E-mail: megan.ypho@inano.au.dk
Tel: +45 4023 1959

b Department of Molecular Biology and Genetics, Aarhus University, CF Møllers Allé 3, DK-8000 Aarhus C, Denmark

c Department of Biology, University of Rome “Tor Vergata”, Via della Ricerca Scientifica 1, Rome, Italy

Abstract

We develop a quantum dot based DNA nanosensor specifically targeting the cleavage–religation activity of an essential DNA-modifying enzyme, human topoisomerase I. The assay has shown great promise in biological crude samples and thus is expected to contribute to clinical diagnostics and anti-cancer therapy.

Graphical abstract: Quantum dot based DNA nanosensors for amplification-free detection of human topoisomerase I

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Article information

DOI
https://doi.org/10.1039/C3RA45557B
Article type
Communication
Submitted
03 Oct 2013
Accepted
04 Nov 2013
First published
05 Nov 2013

RSC Adv., 2014,4, 2491-2494

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Quantum dot based DNA nanosensors for amplification-free detection of human topoisomerase I

M. L. Jepsen, A. Ottaviani, B. R. Knudsen and Y. Ho, RSC Adv., 2014, 4, 2491 DOI: 10.1039/C3RA45557B

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