Issue 4, 2014
From the journal:

RSC Advances

Shell-detachable nanoparticles based on a light-responsive amphiphile for enhanced siRNA delivery†

Hong-Jun Li,a   Hong-Xia Wang,a   Chun-Yang Sun,a   Jin-Zhi Du*a  and  Jun Wang*a  

* Corresponding authors

a School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, P.R. China
E-mail: djzhi@mail.ustc.edu.cn, jwang699@ustc.edu.cn
Fax: +86 551 63600402
Tel: +86 551 63600335

Abstract

Novel light-responsive nanoparticles based on an amphiphile with a single photolabile linker between its hydrophilic head and hydrophobic tail was developed for small interfering RNA (siRNA) delivery. Upon UV exposure, cleavage of the linkage resulted in rapid shell detachment of the nanoparticles, which facilitated siRNA release and enhanced gene silencing efficiency.

Graphical abstract: Shell-detachable nanoparticles based on a light-responsive amphiphile for enhanced siRNA delivery

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Article information

DOI
https://doi.org/10.1039/C3RA44866E
Article type
Communication
Submitted
03 Sep 2013
Accepted
21 Nov 2013
First published
22 Nov 2013

RSC Adv., 2014,4, 1961-1964

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Shell-detachable nanoparticles based on a light-responsive amphiphile for enhanced siRNA delivery

H. Li, H. Wang, C. Sun, J. Du and J. Wang, RSC Adv., 2014, 4, 1961 DOI: 10.1039/C3RA44866E

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