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Issue 46, 2013
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Antithrombogenic properties of a nitric oxide-releasing dextran derivative: evaluation of platelet activation and whole blood clotting kinetics

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Abstract

Controlling platelet activation and clotting initiated by cardiovascular interventions remains a major challenge in clinical practice. In this work, the antithrombotic properties of a polysaccharide-based nitric oxide (NO)-releasing dextran derivative are presented. Total platelet adhesion, platelet morphology and whole blood clotting kinetics were used as indicators to evaluate the anticlotting properties of this material. With a total NO delivery of 0.203 ± 0.003 μmol, the NO-releasing dextran derivative (Dex–SNO) mixed with blood plasma demonstrated a significantly lower amount of platelet adhesion and activation onto a surface and reduced whole blood clotting kinetics. Nearly 75% reduction in platelet adhesion and a significant retention of platelet morphology were observed with blood plasma treated with Dex–SNO, suggesting this to be a potential antiplatelet therapeutic agent for preventing thrombosis that does not have an adverse effect on circulating platelets.

Graphical abstract: Antithrombogenic properties of a nitric oxide-releasing dextran derivative: evaluation of platelet activation and whole blood clotting kinetics

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Publication details

The article was received on 02 Oct 2013, accepted on 10 Oct 2013 and first published on 10 Oct 2013


Article type: Paper
DOI: 10.1039/C3RA45521A
RSC Adv., 2013,3, 24406-24414

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    Antithrombogenic properties of a nitric oxide-releasing dextran derivative: evaluation of platelet activation and whole blood clotting kinetics

    V. B. Damodaran, V. Leszczak, K. A. Wold, S. M. Lantvit, K. C. Popat and M. M. Reynolds, RSC Adv., 2013, 3, 24406
    DOI: 10.1039/C3RA45521A

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