A novel and efficient synthesis of azaarene-substituted 3-hydroxy-2-oxindoles via sp3 C–H functionalization of 2-methyl azaarenes and (2-azaaryl)methanes over a heterogeneous, reusable silica-supported dodecatungstophosphoric acid catalyst

Abstract

A novel and efficient protocol has been developed for the synthesis of azaarene-substituted 3-hydroxy-2-oxindoles via sp³ C–H functionalization of 2-methyl azaarenes and (2-azaaryl)methanes with isatin in good to excellent yield. This is the first example in which heterogeneous, reusable silica supported dodecatungstophosphoric acid (DTP/SiO₂) catalyzed sp³ C–H functionalization of 2-substituted azaarenes and (2-azaaryl)methanes.