Issue 43, 2013
From the journal:

RSC Advances

Efficient palladium-catalyzed cyanation of aryl/heteroaryl bromides with K4[Fe(CN)6] in t-BuOH–H2O using tris(2-morpholinophenyl)phosphine as a ligand†

Tao Zou,a   Xiujuan Feng,*a   Hesong Liu,*b   Xiaoqiang Yu,a   Yoshinori Yamamotoac  and  Ming Baoa  

* Corresponding authors

a State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116023, China
E-mail: fengxiujuan@dlut.edu.cn
Fax: +86-0411-84986180
Tel: +86-0411-84986181

b Department of Dermatology & Venereology, The First Hospital of Jilin University, Changchun 130021, China
E-mail: liuhesong126@126.com
Fax: +86-431-85654528
Tel: +86-431-88782663

c WPI-AIMR (WPI-Advanced Institute for Materials Research), Tohoku University, Sendai 980-8577, Japan

Abstract

A practical method for the synthesis of various aryl/heteroaryl nitriles using non-toxic K4[Fe(CN)6] as the cyanide source is described. The cyanation of aryl/heteroaryl bromides with K4[Fe(CN)6] proceeded smoothly in the presence of a Pd/tris(2-morpholinophenyl)phosphine (L5) catalyst under mild conditions. The corresponding aryl/heteroaryl nitriles were produced in good to excellent yields.

Graphical abstract: Efficient palladium-catalyzed cyanation of aryl/heteroaryl bromides with K4[Fe(CN)6] in t-BuOH–H2O using tris(2-morpholinophenyl)phosphine as a ligand

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C3RA43279C
Article type
Paper
Submitted
28 Jun 2013
Accepted
16 Aug 2013
First published
19 Aug 2013

RSC Adv., 2013,3, 20379-20384

Permissions

Request permissions

Efficient palladium-catalyzed cyanation of aryl/heteroaryl bromides with K4[Fe(CN)6] in t-BuOH–H2O using tris(2-morpholinophenyl)phosphine as a ligand

T. Zou, X. Feng, H. Liu, X. Yu, Y. Yamamoto and M. Bao, RSC Adv., 2013, 3, 20379 DOI: 10.1039/C3RA43279C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements