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Issue 33, 2013
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Ruthenium hydride/nitrogen tridentate ligand-catalyzed α-alkylation of acetamides with primary alcohols

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Abstract

The α-alkylation reaction of acetamides with primary alcohols to afford the corresponding amides was accomplished effectively using RuHCl(CO)(PPh3)3 as a catalyst, nitrogen tridentate ligand L1 as an additive, and KOtBu as a base. While the addition of bpy was effective only for benzylic alcohols, L1 affected the alkylation reaction when both benzylic and non-benzylic type alcohols were used.

Graphical abstract: Ruthenium hydride/nitrogen tridentate ligand-catalyzed α-alkylation of acetamides with primary alcohols

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Publication details

The article was received on 07 Jun 2013, accepted on 21 Jun 2013 and first published on 24 Jun 2013


Article type: Communication
DOI: 10.1039/C3RA42834F
Citation: RSC Adv., 2013,3, 13702-13704

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    Ruthenium hydride/nitrogen tridentate ligand-catalyzed α-alkylation of acetamides with primary alcohols

    T. Kuwahara, T. Fukuyama and I. Ryu, RSC Adv., 2013, 3, 13702
    DOI: 10.1039/C3RA42834F

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