Facile synthesis of Prussian blue @ gold nanocomposite for nonenzymatic detection of hydrogen peroxide

Abstract

A sensitive hydrogen peroxide (H₂O₂) sensor was fabricated based on a Prussian blue @ gold nanocomposite (PB@Au). Au nanoparticles (Au NPs) were first electrodeposited on a glassy carbon electrode (GCE) to increase the conductivity and to catalyze the chemical deposition of PB. Electrochemical measurements showed that the PB@Au modified electrode exhibited good electrocatalytic behavior for the detection of H₂O₂ with a wide linear range from 2 μM to 8.56 mM (R² = 0.9980), a low detection limit down to 0.1 μM (S/N = 3), and a high sensitivity of 39.72 μA mM⁻¹. The sensor also displayed a good anti-interference ability, an acceptable reproducibility, an excellent long-term stability and good repeatability. The desirable recoveries achieved in disinfected fetal bovine serum verified that the developed sensor could have a potential use in the detection of H₂O₂ in real samples. Moreover, the operating simplicity and low expense of the fabrication made the as-prepared electrode attractive.