Issue 26, 2013
From the journal:

RSC Advances

Organocatalytic enantioselective conjugate addition of nitromethane to alkylidenemalonates: asymmetric synthesis of pyrrolidine-3-carboxylic acid derivatives†

Saumen Hajra,*a   Sk Mohammad Aziza  and  Rajat Majia  

* Corresponding authors

a Department of Chemistry, Indian Institute Technology Kharagpur, Kharagpur 721302, India
E-mail: shajra@chem.iitkgp.ernet.in
Fax: +91 3222 255303
Tel: +91 3222 283340

Abstract

A highly enantioselective nitromethane addition to alkylidene malonates catalyzed by cinchona-alkaloid derived thiourea based organocatalyst has been developed that offers a new route to the synthesis of substituted pyrrolidine-3-carboxylic acid derivatives and 3-arylpyrrolidines/pyrrolidones.

Graphical abstract: Organocatalytic enantioselective conjugate addition of nitromethane to alkylidenemalonates: asymmetric synthesis of pyrrolidine-3-carboxylic acid derivatives

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Article information

DOI
https://doi.org/10.1039/C3RA42014K
Article type
Communication
Submitted
28 Feb 2013
Accepted
25 Apr 2013
First published
30 Apr 2013

RSC Adv., 2013,3, 10185-10188

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Organocatalytic enantioselective conjugate addition of nitromethane to alkylidenemalonates: asymmetric synthesis of pyrrolidine-3-carboxylic acid derivatives

S. Hajra, S. M. Aziz and R. Maji, RSC Adv., 2013, 3, 10185 DOI: 10.1039/C3RA42014K

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