Issue 36, 2013

Molecular iodine catalyzed one-pot multicomponent reactions for the synthesis of dihydrochromeno[4,3-b]pyrazolo[4,3-e]pyridin-6(7H)-ones

Abstract

A simple and concise method catalyzed by molecular iodine has been reported for the synthesis of a series of dihydrochromeno[4,3-b]pyrazolo[4,3-e]pyridin-6(7H)-ones (1) using a multicomponent domino reaction of aromatic aldehydes, 4-hydroxycoumarin derivatives and 3-aminopyrazoles. The same catalyst was also found useful for the four component reaction of aromatic aldehydes, 4-hydroxycoumarin, benzoylacetonitrile and hydrazine hydrate. The notable advantages of this method are: good yields, no column chromatography, environmentally friendly catalyst and applicability for diversity oriented synthesis of substituted dihydrochromeno pyrazolo pyridin-6(7H)-one scaffolds using both three and four component reactions.

Graphical abstract: Molecular iodine catalyzed one-pot multicomponent reactions for the synthesis of dihydrochromeno[4,3-b]pyrazolo[4,3-e]pyridin-6(7H)-ones

Supplementary files

Article information

Article type
Paper
Submitted
02 Apr 2013
Accepted
25 Jun 2013
First published
27 Jun 2013

RSC Adv., 2013,3, 15705-15711

Molecular iodine catalyzed one-pot multicomponent reactions for the synthesis of dihydrochromeno[4,3-b]pyrazolo[4,3-e]pyridin-6(7H)-ones

S. Pal, Md. N. Khan, S. Karamthulla and L. H. Choudhury, RSC Adv., 2013, 3, 15705 DOI: 10.1039/C3RA41569D

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