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Issue 21, 2013
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Preparation, characterization, and utilization of multi-functional magnetic-fluorescent composites for bio-imaging and magnetic hyperthermia therapy

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Abstract

This paper describes the synthesis, characterization, and utilization of unique multi-functional magnetic composites that integrate optical and magnetic properties in a single structure for use in hyperthermia therapy, and magnetic and fluorescence imaging. The composites are comprised of nanoscale magnetic core particles that are encapsulated by a silica layer that contains covalently-embedded organic dyes. The morphologies of the nanocomposite particles were characterized by TEM and FE-SEM. Their optical and magnetic properties were evaluated by spectrofluorometry and SQUID magnetometry, respectively. The results demonstrate that the nanocomposites are monodisperse and uniformly spherical with well-defined shell–core structures; moreover, they exhibit high magnetic saturation, produce vivid fluorescence, and can be designed to provide exceptional stability in aqueous solution over a wide range of pH and at elevated temperatures. For the three dyes utilized in the synthesis of these composites, rhodamine B (RhB), fluorescein (Flu), and 7-hydroxycoumarin (Cou), the observed relative stability for the nanoparticles was: RhB-SiO2–Fe3O4 > Flu-SiO2–Fe3O4 > Cou-SiO2–Fe3O4. Additionally, potential uses of these composite nanoparticles as bimodal contrast agents and therapeutic entities are demonstrated.

Graphical abstract: Preparation, characterization, and utilization of multi-functional magnetic-fluorescent composites for bio-imaging and magnetic hyperthermia therapy

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Article information


Submitted
09 Jan 2013
Accepted
05 Mar 2013
First published
05 Mar 2013

RSC Adv., 2013,3, 7838-7849
Article type
Paper

Preparation, characterization, and utilization of multi-functional magnetic-fluorescent composites for bio-imaging and magnetic hyperthermia therapy

S. Rittikulsittichai, B. Singhana, W. W. Bryan, S. Sarangi, A. C. Jamison, A. Brazdeikis and T. R. Lee, RSC Adv., 2013, 3, 7838
DOI: 10.1039/C3RA41002A

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