Issue 25, 2013
From the journal:

RSC Advances

Cu-catalyzed coupling-cyclization in PEG 400 under ultrasound: a highly selective and greener approach towards isocoumarins†

R. Gangadhara Chary,ab   G. Rajeshwar Reddy,a   Y. S. S. Ganesh,a   K. Vara Prasad,a   S. K. Phani Chandra,a   Soumita Mukherjeec  and  Manojit Pal*c  

* Corresponding authors

a Custom Pharmaceutical Services, Dr Reddy's Laboratories Limited, Bollaram Road Miyapur, Hyderabad 500 049, India

b JNT University, Kukatpally, Hyderabad 500072, Andhra Pradesh, India

c Organic and Medicinal Chemistry Department, Dr Reddy's Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad 500046, India
E-mail: manojitpal@rediffmail.com

Abstract

The combination of CuI–K2CO3-PEG 400 facilitated the coupling-cyclization of o-iodobenzoic acid with terminal alkynes under ultrasound, affording a greener and practical approach towards 3-substituted isocoumarins with remarkable regioselectivity. This inexpensive and Pd and ligand free methodology gave rise to various isocoumarins of potential pharmacological interest.

Graphical abstract: Cu-catalyzed coupling-cyclization in PEG 400 under ultrasound: a highly selective and greener approach towards isocoumarins

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Article information

DOI
https://doi.org/10.1039/C3RA40969D
Article type
Communication
Submitted
25 Feb 2013
Accepted
02 May 2013
First published
02 May 2013

RSC Adv., 2013,3, 9641-9644

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Cu-catalyzed coupling-cyclization in PEG 400 under ultrasound: a highly selective and greener approach towards isocoumarins

R. G. Chary, G. R. Reddy, Y. S. S. Ganesh, K. V. Prasad, S. K. P. Chandra, S. Mukherjee and M. Pal, RSC Adv., 2013, 3, 9641 DOI: 10.1039/C3RA40969D

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