Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 20, 2013
Previous Article Next Article

Regioselective enzymatic hydrolysis of hexa-O-acetyl-lactal in a green non-aqueous medium

Author affiliations

Abstract

A purified lipase fraction from Rhizomucor miehei (RML) was immobilized and used to selectively hydrolyze hexa-O-acetyl-lactal 1 to penta-O-acetyl-3-hydroxylactal 2. The reaction was performed in low water content tert-butanol (7% USP water), thus allowing the control of by-product formation. This solvent was superior to the established buffer/acetonitrile system in terms of reagent/product solubility, biocatalyst stability and environmental impact. The reaction was scaled up to 28 g Lāˆ’1 (50 mM) affording the product 2 in very high yield (85%) and purity (98%).

Graphical abstract: Regioselective enzymatic hydrolysis of hexa-O-acetyl-lactal in a green non-aqueous medium

Back to tab navigation

Supplementary files

Article information


Submitted
17 Jan 2013
Accepted
06 Mar 2013
First published
07 Mar 2013

RSC Adv., 2013,3, 7355-7359
Article type
Paper

Regioselective enzymatic hydrolysis of hexa-O-acetyl-lactal in a green non-aqueous medium

T. Bavaro, P. Torres-Salas, D. Ubiali and M. Terreni, RSC Adv., 2013, 3, 7355
DOI: 10.1039/C3RA40266E

Social activity

Search articles by author

Spotlight

Advertisements