Issue 14, 2013
From the journal:

RSC Advances

Boric acid catalyzed Ugi three-component reaction in aqueous media†

Atul Kumar,*a   Deepti Saxenaa  and  Maneesh Kumar Guptaa  

* Corresponding authors

a Medicinal and Process Chemistry Division, Central Drug Research Institute, CSIR, Lucknow, India
E-mail: dratulsax@gmail.com
Fax: +91-522-26234051
Tel: +91-522-2612411

Abstract

B(OH)3 catalyzed Ugi three-component reaction for the synthesis of 2-arylamino-2-phenylacetamide has been developed using aldehydes, amines, and isocyanides in water. The synthesized 2-arylamino-2-phenylacetamides were efficiently converted into α-amino acid via acidic hydrolysis.

Graphical abstract: Boric acid catalyzed Ugi three-component reaction in aqueous media

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Article information

DOI
https://doi.org/10.1039/C3RA23087B
Article type
Paper
Submitted
28 Nov 2012
Accepted
21 Jan 2013
First published
24 Jan 2013

RSC Adv., 2013,3, 4610-4612

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Boric acid catalyzed Ugi three-component reaction in aqueous media

A. Kumar, D. Saxena and M. K. Gupta, RSC Adv., 2013, 3, 4610 DOI: 10.1039/C3RA23087B

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