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Issue 14, 2013
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Regioselective synthesis of densely functionalized, enantiopure, sugar–pyrazole hybrids as potential scaffolds for drug discovery

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Abstract

A versatile new synthetic strategy utilizing MBH chemistry for the assembly of highly functionalized enantiopure sugar–pyrazole hybrid molecules with multiple sites for structural diversification and a non-flat skeleton as potential drug scaffolds is reported. Four representative hybrid molecules were screened for in vitro anti-cancer activity, wherein three of them were found to exhibit good anti-cancer activity.

Graphical abstract: Regioselective synthesis of densely functionalized, enantiopure, sugar–pyrazole hybrids as potential scaffolds for drug discovery

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Article information


Submitted
25 Sep 2012
Accepted
01 Feb 2013
First published
05 Feb 2013

RSC Adv., 2013,3, 4526-4530
Article type
Communication

Regioselective synthesis of densely functionalized, enantiopure, sugar–pyrazole hybrids as potential scaffolds for drug discovery

M. Saquib, I. Husain, R. Kant, S. Meena, H. M. Gauniyal, S. Sinha, P. R. Maulik and A. K. Shaw, RSC Adv., 2013, 3, 4526
DOI: 10.1039/C3RA22287J

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