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Issue 30, 2012
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Unprecedented spiro-annelated sugar isoureas, guanidines and amidines as new families of glycosidase inhibitors

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Abstract

We report the synthesis and evaluation of the hitherto unknown spiranic isoureas, guanidines and amidines derived from carbohydrates as novel glycosidase inhibitors. The effect of the heterocyclic moiety and its substituents on the inhibition was studied, and as a result, a potent α-galactosidase inhibitor (Ki 35 μM) bearing an isoureido motif was achieved.

Graphical abstract: Unprecedented spiro-annelated sugar isoureas, guanidines and amidines as new families of glycosidase inhibitors

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Publication details

The article was received on 25 Jul 2012, accepted on 21 Sep 2012 and first published on 25 Sep 2012


Article type: Paper
DOI: 10.1039/C2RA21561F
RSC Adv., 2012,2, 11326-11335

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    Unprecedented spiro-annelated sugar isoureas, guanidines and amidines as new families of glycosidase inhibitors

    P. Merino-Montiel, Ó. López and J. G. Fernández-Bolaños, RSC Adv., 2012, 2, 11326
    DOI: 10.1039/C2RA21561F

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