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Issue 24, 2012
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Organocatalytic Mannich/cyclization/aromatization sequence: direct synthesis of substituted pyrrole-3-carboxaldehydes

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Abstract

A robust method for the synthesis of substituted pyrrole-3-carboxaldehydes from N-PMP aldimines and succinaldehyde is reported. This reaction involves an organocatalytic direct Mannich reaction, and an acid catalyzed cyclization and oxidative aromatization sequence with high yields (up to 82%).

Graphical abstract: Organocatalytic Mannich/cyclization/aromatization sequence: direct synthesis of substituted pyrrole-3-carboxaldehydes

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Article information


Submitted
22 Jun 2012
Accepted
08 Aug 2012
First published
08 Aug 2012

RSC Adv., 2012,2, 8922-8925
Article type
Communication

Organocatalytic Mannich/cyclization/aromatization sequence: direct synthesis of substituted pyrrole-3-carboxaldehydes

I. Kumar, N. A. Mir, P. Ramaraju and B. P. Wakhloo, RSC Adv., 2012, 2, 8922
DOI: 10.1039/C2RA21258G

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