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Issue 24, 2012
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An efficient and regioselective synthetic approach towards fluorinated quinolinylphosphonates

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Abstract

A synthesis of quinolines substituted by both CF2 and phosphonate groups at the 2- and 3-positions respectively, has been successfully described. In particular, the regioselective heterocyclisation of appropriate (2-cyclohexyliminomethyl)anilines with CF2X-containing alkynylphosphonates promoted by K2CO3 was carried out in dry toluene under reflux. Substituents influenced this reaction either electronically or sterically.

Graphical abstract: An efficient and regioselective synthetic approach towards fluorinated quinolinylphosphonates

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Article information


Submitted
19 Jun 2012
Accepted
06 Aug 2012
First published
28 Aug 2012

RSC Adv., 2012,2, 9135-9141
Article type
Paper

An efficient and regioselective synthetic approach towards fluorinated quinolinylphosphonates

B. Duda, S. N. Tverdomed and G. Röschenthaler, RSC Adv., 2012, 2, 9135
DOI: 10.1039/C2RA21212A

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