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Issue 13, 2012
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Formation of unexpected α-amino amidine through three-component ‘UGI condensation reaction’

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Abstract

The synthesis of a wide variety of α-amino amidine derivatives was accomplished through a one-pot three-component reaction from aromatic aldehydes, aromatic amines and isocyanides, catalyzed by bromodimethylsulfonium bromide (BDMS), in good yields. Some of the salient features of the present protocol are: mild reaction conditions, shorter reaction times, non-aqueous work-up procedure and no need for chromatographic separation.

Graphical abstract: Formation of unexpected α-amino amidine through three-component ‘UGI condensation reaction’

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Publication details

The article was received on 23 Mar 2012, accepted on 20 Apr 2012 and first published on 20 Apr 2012


Article type: Communication
DOI: 10.1039/C2RA20539D
Citation: RSC Adv., 2012,2, 5506-5509

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    Formation of unexpected α-amino amidine through three-component ‘UGI condensation reaction’

    A. T. Khan, S. B. R, M. Lal and M. H. Mir, RSC Adv., 2012, 2, 5506
    DOI: 10.1039/C2RA20539D

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