Issue 16, 2012
From the journal:

RSC Advances

Di-nuclear nonionic magnetic resonance contrast agents using pyrazinyl linking centers†

Guiyan zhao,a   Haolong Li,b   Cuige Lu,a   Yanmeng Xiao,a   Xinxiu Fang,a   Pixin Wang,a   Xuexun Fang,b   Kun Zhao,c   Xinlong Li,c   Shengguo Yin,c   Jingwei Xu*a  and  Wei Yang*a  

* Corresponding authors

a The State Key laboratory of Electroanalytic Chemistry, Changchun Institute of Applied Chemistry, Changchun, Jilin, China
E-mail: yangwei@ciac.jl.cn; jwxu@ciac.jl.cn
Fax: (+)86-431-8526-2349

b Key Laboratory of Molecular Enzymology and Enzyme Engineering of the Ministry of Education, Jilin University, Changchun, PR China

c Department of Radiology, Jilin Province Academy of Chinese Medicine, Changchun, China

Abstract

Two di-nuclear non-ionic MRI contrast agents, (Gd-DO3A)2-BMQX and (Gd-DO3A)2-BMP, have been designed and synthesized by fusing the DO3A units together with a quinoxalinyl or pyrazinyl moiety. They have improved longitudinal relaxivities of 5.23 and 5.16 mM Gd−1 s−1, respectively, at 20 MHz magnet, 37 °C and pH 7.0. In addition, they possess high thermodynamic stability and kinetic inertness. The cytotoxicity studies indicated that the toxicity of these two agents were low. All these properties satisfy the requirements for clinical applications.

Graphical abstract: Di-nuclear nonionic magnetic resonance contrast agents using pyrazinyl linking centers

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Article information

DOI
https://doi.org/10.1039/C2RA20450A
Article type
Communication
Submitted
12 Mar 2012
Accepted
13 Apr 2012
First published
18 Apr 2012

RSC Adv., 2012,2, 6404-6407

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Di-nuclear nonionic magnetic resonance contrast agents using pyrazinyl linking centers

G. zhao, H. Li, C. Lu, Y. Xiao, X. Fang, P. Wang, X. Fang, K. Zhao, X. Li, S. Yin, J. Xu and W. Yang, RSC Adv., 2012, 2, 6404 DOI: 10.1039/C2RA20450A

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