Issue 9, 2012

Synthesis of 3,5-disubstituted pyrazolesvia cyclocondensation of 1,2-allenic ketones with hydrazines: application to the synthesis of 5-(5-methyl-pyrazol-3-yl)-2′-deoxycytidine

Abstract

An efficient procedure for the synthesis of 3,5-disubstituted pyrazoles has been achieved through cyclocondensation reaction of 1,2-allenic ketones and hydrazines under extremely mild conditions. As an application, this methodology provides a highly efficient route to 5-(5-methyl-pyrazol-3-yl)-2′-deoxycytidine.

Graphical abstract: Synthesis of 3,5-disubstituted pyrazoles via cyclocondensation of 1,2-allenic ketones with hydrazines: application to the synthesis of 5-(5-methyl-pyrazol-3-yl)-2′-deoxycytidine

Supplementary files

Article information

Article type
Paper
Submitted
15 Feb 2012
Accepted
15 Feb 2012
First published
16 Feb 2012

RSC Adv., 2012,2, 3772-3777

Synthesis of 3,5-disubstituted pyrazoles via cyclocondensation of 1,2-allenic ketones with hydrazines: application to the synthesis of 5-(5-methyl-pyrazol-3-yl)-2′-deoxycytidine

S. Guo, J. Wang, D. Guo, X. Zhang and X. Fan, RSC Adv., 2012, 2, 3772 DOI: 10.1039/C2RA20274C

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